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Gaultier never received formal training as a designer. Instead, he started sending sketches to famous couture stylists at an early age. Pierre Cardin was impressed by his talent and hired him as an assistant in 1970.
His first individual collection was released in 1976 and his characteristic irreverent style dates from 1981, and he has long been known as the enfant terrible of French fashion. Many of Gaultier's following collections have been based on street wear, focusing on popular culture, whereas others, particularly his Haute Couture collections, are very formal yet at the same time unusual and playful.
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Gaultier caused shock by using unconventional models for his exhibitions, like older men and full-figured women, pierced and heavily tattooed models, and by playing with traditional gender roles in the shows. This earned him both criticism and enormous popularity.
At the end of the 1980s, Gaultier suffered some personal losses, including his lover and business partner Francis Menuge, who died of AIDS-related causes.
Gaultier has designed costumes for many films, including Luc Besson's The Fifth Element, Pedro Almodóvar's Kika, Peter Greenaway's The Cook, the Thief, His Wife & Her Lover, and Jean-Pierre Jeunet's La Cité des enfants perdus (The City of Lost Children).
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Gaultier has designed a number of the costumes and outfits worn by rocker Marilyn Manson, including the outfits for Manson's Golden Age of Grotesque album.
In addition to being a fashion designer, Jean-Paul Gaultier is known for a popular line of perfumes distinctively packaged in bottles referencing his love of corsetry for women and the matelot image for men.